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CARLOS ALBERTO FOSSATI

TITULOS OBTENIDOS. Licenciado en Ciencias Bioquímicas (1970) y Doctor en Ciencias Bioquímicas, Orientación Bioquímica Clínica. Facultad de Ciencias Exactas, Universidad Nacional de La Plata.

POSICION ACTUAL

- Miembro de la Carrera del Investigador del Consejo Nacional de Investigaciones Científicas y Técnicas. Categoría: Investigador Principal

- Profesor Titular Ordinario Dedicación Exclusiva. Cátedra: Inmunología. Facultad de Ciencias Exactas, Universidad Nacional de La Plata.

LUGAR DE TRABAJO

- Cátedra de Inmunología. Facultad de Ciencias Exactas, U.N.L.P. Calles 47 y 115 - (1900) La Plata. Tel (0221) 423-5333 int 45. Email afossati@biol.unlp.edu.ar

- Instituto de Estudios de la Inmunidad Humoral (IDEHU, UBA-CONICET). Facultad de Farmacia y Bioquímica, UBA. Junín 956, 4o Piso. (1113) Capital Federal. Tel. (011) 4964-8259/60 Int. 113. Fax: 4964-0024. Email afossati@ffyb.uba.ar

DIRECCION DE TESIS APROBADAS: 11

TRABAJOS CIENTIFICOS PUBLICADOS Y/O EN PRENSA EN REVISTAS NACIONALES E INTERNACIONALES: 80

PUBLICACIONES EN TEXTOS: 5

COMUNICACIONES EN CONGRESOS, JORNADAS Y SIMPOSIOS NACIONALES: 97

INTERNACIONALES: 69

ORGANIZACION DE CURSOS DE POSGRADO: 19

PARTICIPACION EN EL DICTADO DE CURSOS DE POSGRADO: 66

DICTADO DE SEMINARIOS Y CONFERENCIAS: 28

SUBSIDIOS RECIBIDOS: CONICET, CIC, ANPCyT, Antorchas, UNLP, UBA, Ministerio de Salud de la Nación.

PREMIOS Y DISTINCIONES: "

"Xeme Grand Concours International 1978". Academie Internationale de Lutece, París

Premio "Dr. Leonardo Satz" 2002, Sociedad Argentina de Inmunología.

Premio "Fundación Manzullo" 1998, Asociación Argentina de Zoonosis.

Premio "Patricio Cossio", 1997, Fundación Cossio

 

CURRICULUM VITAE

 

Licenciado en Ciencias Bioquímicas y Dr. en Bioquímica, Facultad de Ciencias Exacta, UNLP.

Profesor Adjunto Dedicación Exclusiva a cargo de Inmunología, Facultad de Ciencias Exactas, UNLP. Investigador Principal del CONICET. Perfeccionamiento pos doctoral: National Institute for Biologicals Standars and Control y St. Bartholomew´s School of Medicine, Londres, Inglaterra; especialización en obtención, caracterización y utilización de anticuerpos monoclonales.

Líneas de investigación. Estudio de la respuesta inmune y desarrollo de métodos de diagnóstico para enfermedades por intolerancias alimentarias y por infección con Brucella. Desarrollo de vacunas subcelulares

 

PUBLICACIONES

Trabajos Científicos publicados en Revistas Periódicas

1.  "A novel radioimmunometric approach to the assay of components of human haemostasis assay of plasma fibrinopeptide a level". P.J.Gaffney, F.Joe, M.Mahamoud, C.A.Fossati, M.Spitz. Thrombosis Research 19, 815-822 (1980) pISSN: 0049-3848

2.  "Participation of Diffusible Products in the in vivo Immune Primary Response to Red Blood Cells". C.A.Fossati, M.Spitz. Immunology 44, 11-15 (1981) pISSN: 0019-2805

3.    "Anticuerpos Homogéneos Obtenidos por Fusión de Células Somáticas. Hibridomas". C.A.Fossati, R.A.Margni. Revista Asociación Bioquímica Argentina 46, 48-58 (1982)

4.    "Antibodies to poliovirus detected by immuno-radiometric assay with a monoclonal antibody". M.Spitz, C.A.Fossati, G.C.Schild, L.Spitz, M.Brasher. Journal of Virological Methods 5, 101-111 (1982) pISSN: 0166-0934

5.    "Factores difusibles como activadores de la respuesta inmune primaria in vivo". C.A.Fossati. Medicina (Buenos Aires) 43, 63-68 (1983) pISSN: 0025-7680

6.    "Anticuerpos Monoclonales como Reactivos de Laboratorio". C.A.Fossati. Revista Argentina de Microbiología 15, 57-64 (1983). pISSN 0325-7541

7.    "Reacciones de Precipitación Mediante Mezcla de Anticuerpos Monoclonales Dirigidos contra Diferentes Determinantes Isotípicos de IgG Humana". C.A.Fossati. Inmunología 4, 146-150 (1985) pISSN 0213-9626 1988

8.    "Chromatofocusing: a useful method for murine IgG1 monoclonal antibody purification". L.Morelli, J.R.Ronco, J.Leoni, C.A.Fossati. Comunicaciones Biológicas 7, 27-37 (1988)

9.    "Symmetric and Asymmetric IgG Antibodies are Synthesized by the same Cellular Clone". L.Morelli, J.Leoni, C.A.Fossati, R.A.Margni. Molecular Immunology 26, 789-792 (1989) pISSN: 0161-5890

10.         "Anticuerpos Monoclonales contra Antígenos de Posible Utilidad Diagnóstica en Brucelosis Humana". L.Morelli, C.P.Rubbi, F.A.Goldbaum, C.A.Fossati. Acta Bioquímica Clínica Latinoamericana 23, 309-314 (1989) pISSN 0325-2957

11.         "Isolation of a Trypanosoma cruzi Antigen by Affinity Chromatography with a Monoclonal Antibody. Preliminary Evaluation of its Possible Aplications in Serological Test". C.H.Carbonetto, E.L.Malchiodi, M.Chiaramonte, E.D. de Isola, C.A.Fossati, R.A.Margni. Clinical and Experimental Immunology 82, 93-96  (1990) pISSN: 0009-9104

12.         "Human brucellosis: immunoblotting analysis of three brucella abortus antigenic fractions allows the detection of components of diagnostic importance". F.A.Goldbaum, Laura Morelli, J.Wallach, C.P.Rubbi, C.A.Fossati. Medicina 51, 227-232 (1991)

13.         "Differentiation Between Active and Inactive Human Brucellosis by Measuring Antiprotein Humoral Immune Response". F.A.Goldbaum, C.P.Rubbi, J.E.Wallach, S.E.Miguel, P.C.Baldi and C.A.Fossati. Journal of Clinical Microbiology, 30, 604-607 (1992) pISSN: 0095-1137

14.         "Caracterización de un Antígeno de Trypanosoma cruzi Purificado con Anticuerpos Monoclonales: Utilidad Diagnóstica y Análisis de su Inmunogenicidad". N.W. Zwirner, E.L. Malchiodi, M.G. Chiaramonte, R.A. Margni, M. Esteva, C.A. Fossati. Inmunología 11, 120-127 (1992) 0213-9626

15. "Analysis of oligosaccharides involved in asymmetrical glycosylation of IgG monoclonal antibodies". L.Morelli, L.Plotkin, J.Leoni, C.A.Fossati, R.A.Margni. Molecular Immunology 7, 695-700 (1993). pISSN: 0009-9104

16. "Characterization of a 18 Kda Brucella Cytoplasmic Protein Which Appears To Be a Serological Marker Of Active Infection of Both Human and Bovine Brucellosis". F.A. Goldbaum, J. Leoni, J.C. Wallach, C.A. Fossati. Journal of Clinical Microbiology  31, 2141-2145 (1993) pISSN: 0095-1137

17.         "Urban Outbreak of Brucella melitensis Infection in an Argentine Family: Clinical and Diagnostic Aspects". J.C.Wallach, S.E.Miguel, P.C.Baldi, E.Guarnera, F.A.Goldbaum, C.A.Fossati. FEMS Immunol. and Med. Microbiol. 8, 49-56 (1994). pISSN: 0928-8244

18.         "Removal of LPS from a Brucella cytoplasmic fraction by affinity chromatography with an anti-LPS monoclonal antibody as immunosorbent". F.A. Goldbaum, C.P. Rubbi, C.A. Fossati. Journal of Medical Microbiology 40, 174-178 (1994) pISSN: 0022-2615

19.         "A lytic Monoclonal Antibody to Trypanosoma cruzi Bloodstream Trypomastigotes Which Recognizes an Epitope Expressed in Tissues Affected in Chagas' Disease". N.W. Zwirner, E.L. Malchiodi, M. Chiaramonte, C.A.Fossati. Infection and Immunity 62, 2483-2489 (1994) pISSN: 0019-9567

20.         "Brucella abortus cytoplasmic proteins used as antigens in an ELISA potentially useful for the diagnosis of canine brucellosis". P.C.Baldi, M.M.Wanke, M.E.Loza, C.A.Fossati. Veterinary Microbiology 41, 127-134 (1994) pISSN: 0378-1135

21.         "Fractionation Of Wheat, Barley And Rye Prolamins By Cation Exchange FPLC". F.G. Chirdo, C.A. Fossati and M.C Añón. Journal Agriculture and Food Chemistry 42, 2460-2465 (1994) pISSN 0021-8561

22.         "Methachromatic effect in homologous groups of wheat, barley and rye prolamines". F.G. Chirdo, C.A. Fossati, M.C. Añón. Journal of Food Biochemistry 18, 185-197 (1995) pISSN: 0145-8884

23.         "Serodiagnóstico de la brucelosis humana por aglutinación directa. Problemas de interpretación de resultados obtenidos con diferentes antígenos comerciales". Baldi, P.C., Wallach J.C., Fossati C.A. Acta Bioquímica Clínica Latinoamericana 29, 147-157 (1995) pISSN 0325-2957

24.         “Modulation of cardiac physiology by an anti-Trypanosoma cruzi monoclonal antibody after interaction with myocardium”. Cremaschi G, Zwirner N.W, Gorelik G, Malchiodi E.L, Chiaramonte M.G, Fossati C.A, Sterin Borda L. FASEB Journal, 9 1482-1488 (1995) pISSN: 0892-6638

25.         “Optimization of a Competitive ELISA with Polyclonal Antibodies for Quantification of Prolamins in Foods". Chirdo F.G., Añón M.C., Fossati C.A. Food and Agricultural Immunology 7, 333-343 1995 pISSN 0954-0105

26.         "N-glycanase treatment of f(ab')2 derived from asymmetric murine igg3 mab determines the adcquisition of precipitating activity". I. Mathov, L. Plotkin, L. Squiquera, C.A. Fossati, R.A. Margni, J. Leoni. Molecular Immunology 32, 1123-1130 (1995) pISSN: 0161-5890

27.         “Serological cross reactivity between Brucella abortus and Yersinia enterocolitica 0:9. A) Immunoblot analysis of the antibody response to Brucella protein antigens in bovine brucellosis”. R. Kittelberger, F.Hilbinik, M.F. Hansen, M. Penrose, G.W. de Lisle, J.J. Letesson, B. Garin-Bastuji, J. Searson, C.A. Fossati, A. Cloeckaert, G. Shurig. Veterinary Microbiology 47, 257-270 (1995) pISSN: 0378-1135

28.          “Serological Follow-Up of Human Brucellosis by Measuring IgG Antibodies Directed to Lipopolysacharide and Cytoplasmic Proteins of Brucella Species”. P.C. Baldi, S.E. Miguel, C.A. Fossati, J.C Wallach. Clinical Infectious Diseases 22, 446-455 (1996) pISSN: 1058-4838

29.         "Identification of casein as the major allergenic and antigenic protein of cow’s milk". Docena G.H., Fernández R., Chirdo F.G., Fossati C.A. Allergy 51, 412-416 (1996) pISSN: 0105-4538

30.         “Humoral Immune Response against Lipopolysaccharide and Cytoplasmic Proteins of Brucella abortus in Cattle Vaccinated with B. abortus s19 or Experimentally Infected with Yersinia enterocolitica Serotype 0:9”. Baldi, PC, Giambartolomei, GH, Goldbaum, FA, Abdón, LF., Velikovsky, A., Kittelberger, R. and Fossati, CA. Clinical and Diagnostic Laboratory Immunology 3, 472-476 (1996) pISSN: 1071-412X

31.         “Interspecies cross-reactivity of a monoclonal antibody directed against wheat chloroplast fructose 1,6-biphosphatase”. K. Hagelin, R. Rodriguez-Suarez, F. Katzen, R.A. Wolosiuk, P.C. Baldi, G.H. Giambartolomei, C.A. Fossati, T. Dyer. Cellular and Molecular Biology 42, 673-682 (1996) pISSN: 1381-1932

32.         “Influence of Thermal Treatment of Food on the Immunochemical Quantification of Gliadin”. Rumbo M, Chirdo F.G., Fossati C.A.; Añón M.C. Food and Agricultural Immunology 8, 195-203, (1996). ISSN p0954-0105

33.         “Analysis of Structural Properties and Immunochemical Reactivity of Heat Treated Ovalbumin”. M. Rumbo, F.G. Chirdo, C.A. Fossati, M.C. Añón. Journal of Agriculture and Food Chemistry. 44, 3793-3798 (1996) pISSN 0021-8561

34.         “Desarrollo de un ELISA de alta detectabilidad y especificidad para la cuantificación de gliadinas en alimentos destinados a enfermos celíacos”. F.G. Chirdo, M.C. Añón, C.A. Fossati. Acta Bioquímica Clínica Latinoamericana 30, 389-399 (1996) pISSN 0326-2957

35.          “Immunoblotting of Gliadins Separated by Acid PAGE. Analysis of Electrotransference Conditions”. Rumbo M., Chirdo F.G., Añón M.C. , Fossati C.A. Food and Agricultural Immunology 9, 135-139 (1997) pISSN 0954-0105

36.         “Characterization of Anti-Idiotypic Antibodies that Bind Antigen and Anti-idiotype”. F.A. Goldbaum, C.A. Velikovsky, W. Dal’Acqua, C.A. Fossati, R.A. Fields, B.C. Braden, R.J. Poljak, R.A Mariuzza. Proc. Natl. Acad. Sci. U.S.A. 94, 8697-8701 (1997). pISSN: 0027-8424

37.         “Diagnosis of canine brucellosis by detection of serum antibodies against an 18 kDa cytoplasmic protein of Brucella spp.”. P.C. Baldi, M.M. Wanke, M.E. Loza, N. Monachesi, C.A. Fossati. Veterinary Microbiology 57, 273-281 (1997) pISSN: 0378-1135

38.           “Detection and characterization of antibodies specific to food antigens (gliadin, ovoalbumin and b-lactoglobulin) in human serum, saliva, colostrum and milk”. Rumbo, M., Chirdo, F.G., Añón, M.C. and Fossati, C.A. Clinical and Experimental Immunology 112 (3), 453-458 (1998). pISSN: 0009-9104

39.          “Development of High-sensitivity Enzyme Immunoassays for Gliadin Quantification using the Streptavidin-Biotin Amplification System”. Chirdo, F.G., Añón, M.C. and Fossati, C.A. Food and Agricultural Immnulogy 10 (2), 143-15 (1998) . ISSN p0954-0105

40.           "Presence of High Levels of Non-Degraded Gliadin in Breast Milk from Healthy Mothers". Chirdo F.G., Rumbo M., Añón M.C. and Fossati C.A. Scandinavian Journal of  Gastroenterology 33 (11): 1186-1192, (1998) pISSN: 0036-5521

41.         "Serological Investigation of Latex Allergy in Argentina." Docena G., Fernández R., Ocampo M., Fossati C. Allergy and Asthma Proceedings 20 (2): 99-106 (1999) pISSN: 1088-5412

42.         “Detection of allergens in Aedes Albifasciatus Mosquito (Diptera: Culicidae) extracts by immunological methods”. G H Docena, P Benítez, R E Campos, A Macia, R Fernández, C A Fossati. Journal of Investigational Allergology & Clinical Immunology  9 (3): 165-171 (1999) pISSN: 1018-9068

43.         "Preparative Fractionation of Gliadins by Electrophoresis At pH 3.1 (A-PAGE)". M. Rumbo, F.G. Chirdo, SA. Giorgeri, C.A. Fossati and M.C. Añón. Journal Agricultural and Food Chemistry. 47 (8), 3243-3247 (1999) pISSN: 0021-8561

44.          “The 18 kDa Cytoplasmic Protein of Brucella species - an Antigen Useful for Diagnosis - is a Lumazine Synthase”. Goldbaum FA, Velikovsky CA, Baldi PC, Mörtl S, Bacher A, Fossati CA. Journal of Medical Microbiology 48: 833-839 (1999) pISSN: 0022-2615

45.         “Detection of Antibodies to Brucella Cytoplasmic Proteins in the Cerebrospinal Fluid of Patients with Neurobrucellosis”. Baldi PC, Araj GF, Raccaro GC, Wallach JC, Fossati CA. Clinical and Diagnostic Laboratory Immunology 6 (5), 756-759 (1999) pISSN: 1071-412X

46. "Analysis of Anti-Gliadin Antibodies by Immunoblot Analysis and Enzyme-Linked Immunosorbent Assay  Using Gliadin Fractions As Antigens". Fernando G. Chirdo, M. Rumbo, P. Carabajal, N. Castagnino, E. Mavromatopulos, V. Cirincione, M. C. Añón and C. A. Fossati. Journal of Pediatrics Gastroenterology and Nutrition. 29: 171-177 (1999) pISSN 0277-2116

47. "Analysis of Anti-Prolamin Monoclonal Antibody Reactivity Using Prolamin Fractions Purified by Preparative Electrophoresis". Rumbo M, Chirdo F.G., Fossati, C.A., Añón M.C. Food and Agricultural Immunology 12: 41-52 (2000). ISSN p0954-0105

48. "Identification of allergenic proteins in condoms by immunoenzymatic methods". Docena G.H,  Benítez P, Fernández R., Fossati C.A. Annals of Allergy Asthma and Immunology 84: 77-83 (2000). pISSN: 1081-1206

49. "Structural, functional and immunological studies on a polymeric bacterial protein". Baldi PC, Velikovsky CA, Braden BC, Giambartolomei GH,  Fossati CA, Goldbaum FA. Brazilian Journal of Medical and Biological Research 33:741-747 (2000) ISSN 0100-879X

50. “Determination of Anti-w-Gliadin Antibodies in Serological Test for Coeliac Disease”. Chirdo F.G., Rumbo M., Carabajal P., Mavromatopulos E., Castagnino N., Añón M.C. and Fossati C.A. Scandinavian Journal of Gastroenterology. 35: 508-516 (2000). pISSN: 0036-5521

51. “Determinación de anticuerpos contra proteínas citoplasmáticas de brucella por ELISA para la detección de casos crónicos de brucelosis canina”. Wanke MM, Monachesi NE, Loza ME, Rutter B, Baldi PC, Fossati CA. Selecciones Veterinarias 8:308-311, 2000.pISSN 0327-859x

52.  "Single-shot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies. Persistent expression of DNA". C.A. Velikovsky, J. Cassattaro, M. Sanchez, C.A. Fossati, L. Fainboim, M. Spitz. Journal of Immunological Methods 244, 1-7 (2000) pISSN: 0022-1759

53. "Limited Diagnostic Usefulness of Antibodies to Cytoplasmic Proteins of Brucella in Early-treated Human Brucellosis". Baldi PC, Giambartolomei GH, Wallach JC, Velikovsky CA, Fossati CA. Scandinavian Journal of Infectious Diseases 33 (3), 200-205 (2001) pISSN: 0036-5548

54. “Respuesta inmune dirigida contra antígenos proteicos de Brucella spp. durante la infección experimental y la inmunización” Velikovsky CA, Cassataro J, Giambartolomei GH, Baldi PC, Bowden R, Spitz M, Fossati CA. Investigaciones Veterinarias, 3 (1-2): 193-196 (2001). ISSN 1514-6634

55.  “Analysis of the Effects of Heat Treatment on Gliadin Immunodhemical Quantification Using a Panel of Anti-Prolamin Antibodies”. M. Rumbo, F.G. Chirdo, C.A. Fossati, Añón M.C. Journal of Agricultural and Food Chemistry,. 49: 5719-5726 (2001) pISSN: 0021-8561

56.  “In vitro presentation of gliadin-derived peptides by different cell lines”. Chirdo F.G., Zwirner N.W., Rumbo M, Fossati C.A. Clinica Chimica Acta.. 317(1-2): 151-158 (2002). pISSN: 0009-8981

57. “Evaluation of the residual antigenicity and allergenicity of cow’s milk substitutes by in vitro tests”, Docena GH, Rozenfeld P, Fernandez R And Fossati CA. Allergy 57:  83-91 (2002). pISSN 0105-4538

58. “Diagnostic Usefulness of Antibodies Against Ribosome Recycling Factor from Brucella melitensis in Human and Canine Brucellosis”. J Cassataro, MV Delpino, CA Velikovsky, L Bruno, CA Fossati, CP Baldi. Clinical and Diagnostic Laboratory Immunology 9(2), 366-369 (2002). pISSN 1071-412X

59.  “Clinical and Diagnostic Aspects of Relapsing Meningoencephalitis due to Brucella suis”. J.C. Wallach, P.C. Baldi, C.A. Fossati. Eur. J. Clin. Microbiol Infect. Dis. 21, 760-762 (2002). pISSN: 0934-9723

60. “Immunogenicity of the Brucella melitensis recombinant ribosome recycling factor-homologous protein and its cDNA”. J Cassataro, CA Velikovsky, GH Giambartolomei, S Estein, L Bruno, A. Cloeakaert, RA Bowden, M Spitz, CA Fossati,. Vaccine 20: 1660-1669 (2002) pISSN: 0264-410X

61. “Fractionation of secalins and hordeins by preparative electrophoresis at acid pH”. M. Rumbo, AI Margheritis, FG Chirdo, SA Giorgeri, CA Fossati, MC Añón. European Food Research and Technology. 214: 198-201 (2002)  pISSN 1438-2377

62. "A DNA Vaccine Encoding Lumazine Sythase from Brucella abortus Induces Protective Immunity in BALB/c Mice". Carlos A. Velikovsky, Juliana Cassataro, Guillermo H Giambartolomei, Fernando A. Goldbaum, Silvia Estein, Raul A. Bowden, Laura Bruno, Carlos A. Fossati and Moisés Spitz. Infection and Immunity. 70(5):2507-2511 (2002) pISSN: 0019-9567

63. “Diminished Production of T Helper 1 Cytokines Correlates with T-Cell Unresponsiveness to Brucella Cytoplasmic Proteins in Chronic Human Brucellosis”. G.H. Giambartolomei, M.V. Delpino, M.E. Cahanovich, J.C. Wallach, P.C. Baldi, C.A. Velikovsky, C.A. Fossati. Journal of Infectious Diseases 186(2): 252-259 (2002) pISSN: 0022-1899

64. “Detection and identification of a soy protein component that cross-reacts with caseins from cow milk”, Rozenfeld P, Docena GH, Añón MC, Fossati CA. Clinical and Experimental Immunology, 130:49-58 (2002). pISSN: 0009-9104

65.  “Antibodies to CP24 protein of Brucella melitensis lack diagnosis usefulness in bovine brucellosis”  M Victoria Delpino, Juliana Cassataro, Carlos A. Fossati, Pablo C Baldi. Veterinary Microbiology 93, 101-107 (2003 pISSN: 0378-1135

66. Brucella Lumazine Snthase Elicits a Mixed TH1 TH2 Immune Responseand Induce Protection in Mice Challenged  with Brucella abortus 554 Independelntly of the Adjuvant Formulation Used” C.A. Velikovsky, J. Cassataro, S. Estein, R.A. Bowden, L. Bruno. C.A. Fossati, G. H Giambartolomei. Infection and Immunity 2003 Oct 71(10):5750-5755. pISSN: 0019-9567

67.  “Antibody Reactivity to Omp31 from Brucella melitensis in Human and Animal Infections by Smooth and Rough Brucellae”. Cassataro J, Pasquevich K, Bruno L, Wallach JC, Fossati CA, Baldi PC. Clinical and Diagnostic Laboratory Immunology. 2004; 11: 111-114. pISSN: 1071-412X

68. “Human infection with the M- strain of Brucella canis.” Wallach JC, Giambartolomei GH, Baldi PC, Fossati CA. Emerging Infectious Diseases, 10:146-148 (2004)  pISSN: 1080-6040

69. “Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides”. D. A. Laplagne, V. Zylberman1, N. Ainciart, M. W. Steward, E. Sciutto, C. A., Fossati, F. A. Goldbaum.  PROTEINS:. 2004 Aug 18;57(4):820-828. pISSN: 0887-3585

70. “Modulatory effects on myocardial physiology induced by an anti-Trypanosoma cruzi monoclonal antibody involve recognition of major antigenic epitopes from b1-adrenergic and M2-muscarinic cholinergic receptors without requiring receptor cross-linking”, Graciela Cremaschi, Marisa M. Fernández, Gabriela Gorelik, Juan C. Goin, Carlos A. Fossati, Norberto W. Zwirner and Emilio L. Malchiodi. Journal of Neuroimmunology . 2004 Aug;153(1-2):99-107. pISSN: 0165-5728

71. . “Occurrence and Potential Diagnostic Applications of Serological Cross-Reactivities between Brucella and Other Alpha-Proteobacteria”. M. Victoria Delpino, Carlos A. Fossati, and Pablo C. Baldi. Clinical and Diagnostic Laboratory Immunology, Sept. 2004, p. 868–873

72. “Lipoproteins, not Lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus”, Guillermo H. Giambartolomei, Astrid Zwerdling, Juliana Cassataro, Laura Bruno, Carlos A. Fossati, and Mario T. Philipp. J Immunol. 2004 Oct 1;173(7):4635-42. pISSN: 0022-1767.

73. “Serological prevalence of anti-latex IgE antibodies in unselected blood donors in Argentina”. Docena GH, Fossati CA. J Investig Allergol Clin Immunol. 2005;15(1):46-9. pISSN: 1018-9068

74. “Development of an immunochemical method to detect Lactobacillus kefir”. GL Garrote, MA Serradell, AG Abraham, MC Añón, CA Fossati, GL De Antoni. Food and Agricultural Immunology (2005) 16, 1-4; 221 - 233 pISSN 0954-0105

75.  “Mutation in the P36 gene of Mycobacterium bovis provokes attenuation of the bacillus in a mouse model”.  Bigi F, Gioffre A, Klepp L, Santangelo MP, Velikovsky CA, Giambartolomei GH, Fossati CA, Romano MI, Mendum T, McFadden JJ, Cataldi A . Tuberculosis (Edinb). 2005 Jul;85(4):221-6. pISSN: 1472-9792

76.  “A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response”. Cassataro J, Velikovsky CA, de la Barrera S, Estein SM, Bruno L, Bowden R, Pasquevich KA, Fossati CA, Giambartolomei GH Infect Immun. 2005 Oct;73(10):6537-46. pISSN: 0019-9567

77.  Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection”. Cassataro J, Estein SM, Pasquevich KA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH. Infect Immun. 2005 Dec;73(12):8079-88. pISSN: 0019-9567

78. “A successful approach for the detection of Fabry patients in Argentina”. Rozenfeld PA, Tarabuso A, Ebner R, Ramallo G, Fossati CA. A. Clin Genet 2006: 69: 344–348. pISSN: 0009-9163

79. “Brucella outer membrane protein Omp31 is a haemin-binding protein”. Delpino MV, Cassataro J, Fossati CA, Goldbaum FA, Baldi PC. Microbes Infect. 8 (2006), 1203-1208. pISSN: 1286-4579

80.  "Immunofluorescence Detection of Globotriaosylceramide (Gb3) Deposits in Conjunctival Biopsies of Fabry Disease Patients". Paula A Rozenfeld, Oscar Croxatto, Roberto Ebner, Carlos A. Fossati. Clinical and Experimental Ophthalmology. 2006; 34:689-694 pISSN 0721-832X

81. “A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in mice.” Delpino MV, Marchesini MI, Estein SM, Comerci DJ, Cassataro J, Fossati CA, Baldi PC. Infect. Immun 2007 Jan; 75(1):299-305. Epub 2006 Nov 6. pISSN: 0019-9567

82. “Improved Immunogenicity of a Brucella DNA vaccine encoding Outer Membrane Protein 31 (Omp31) by Recombinant Omp31 Boosting”. Cassataro J, Velikovsky CA, Bruno, L, Estein S, De la Barrera S, Bowden RA, Fossati CA, Giambartolomei GH. Clin Vaccine Immunol. 2007 Apr 11; [Epub ahead of print] pISSN 1556-6811

83. “A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of  protection against B. ovis than Rev-1 vaccination.” Cassataro J, Pasquevich KA, Estein SM , Laplagne D, Velikovsky CA, De la Barrera S, Bowden RA, Fossati CA, Giambartolomei GH, Goldbaum FA. Vaccine. 2007 May 30;25(22):4437-4446. Epub 2007 Apr 2. pISSN: 0019-9567

84. “Hypogammaglobulinemia secondary to cow-milk allergy in children under 2 years of age”. Liliana Bezrodnik, Andrea Gómez Raccio, Laura Canil, Maria Amanda Rey, Patricia Carabajal, Carlos Fosatti, Guillermo Docena. Immunology. 2007 May 11; [Epub ahead of print] pISSN: 0019-2805

85.  “Partial Protection against Brucella Infection in Mice by Immunization with Nonpathogenic Alphaproteobacteria” M. Victoria Delpino, Silvia M. Estein, Carlos A. Fossati, and Pablo C. Baldi1. Clinical and Vaccine Immunology, oct. 2007, p. 1296–1301

Trabajos Publicados en Proceedings de Congresos

1.    "Efecto metacromático en proteínas derivadas de trigo, cebada y centeno". F.G. Chirdo, C.E. Lupano, C.A. Fossati y M.C. Añon. Actas del III Congreso Mundial de Tecnología de Alimentos. Barcelona (España), 20 al 23.02.91.

2.    "Desarrollo de un método inmunoquímico para la cuantificación de prolaminas en alimentos". F.G. Chirdo, C.A. Fossati y M.C. Añón. Actas VI Congreso Argentino de Ciencia y Tecnología de Alimentos. Pág. 297-299. Buenos Aires, 06 al 08.04.94.

3.    "Producción de anticuerpos monoclonales anti-gliadinas". F.G. Chirdo, C.A. Fossati y M.C. Añón. Actas VI Congreso Argentino de Ciencia y Tecnología de Alimentos. Pág. 300-302. Buenos Aires, 06 al 08.04.94.

4.     “Análisis estructural y funcional de la proteína de 18 kDa de Brucella spp, un marcador de infección brucelar activa”. CA Velikovsky, P Baldi, GC Racaro, CA Fossati, FA Goldbaum. Boletín de la Asociación Argentina de Zoonosis, N° 8, (1998).

5.    “Characterization of anti-prolamin monoclonal antibody reactivity and Development of high sensitive enzyme immunoassays for gliadin determination”. Chirdo F.G., Rumbo M., Añón M.C. and Fossati C.A. Proceeding del 13th Meeting of Working Group on Prolamin Analysis and Toxicity. Pag; 59-65. Barcelona (España), 05 al 08.11.98.

6.     “Diagnóstico y seguimiento de la brucelosis humana mediante nuevos métodos serológicos”. J.C. Wallach, P.C. Baldi, F.A. Goldbaum, C.A. Velikovsky, C.A. Fossati. Revista Argentina de Microbiología, 31 (Supl. 1) 46-48 (1999)

7.    “Determinación de anticuerpos anti-proteínas para el diagnóstico de la brucelosis en animales”. P.C. Baldi, F.A. Goldbaum, C.A. Velikovsky, J.C. Wallach, C.A. Fossati. Revista Argentina de Microbiología, 31 (Supl. 1) 49-51 (1999).

8.    "Effect of heat treatment on gliadin immunochemical quantification in food". Rumbo M., Chirdo F.G., Añón M.C. and Fossati C.A. Proceeding of the 14th Meeting of Working Group on Prolamin Analysis and Toxicity. Pag. 63-70. Stuttgart. Alemania. (1999).

9.     “Production of anti-human transglutaminase monoclonal antibodies” . Chirdo F.G., Osman A.A., Mothes T., Rumbo M., Añón M.C. and Fossati C.A. Proceedings of the 15th Meeting of Working Group on Prolamin Analysis and Toxicity. Pag. 173 - 176  Noviembre 8-12, 2000. Merano, Italia. M. Stern Ed. Tubingen, Alemania.

10.         “Use of different standard solutions in gliadin immunochemical quantification” . Rumbo M., Chirdo F.G., Barclay A., Margheritis A., Fossati C.A. and Añón M.C. Proceedings of the 15th Meeting of Working Group on Prolamin Analysis and Toxicity. Pag. 89 -95. Noviembre 8-12, 2000. Merano, Italia. M. Stern Ed. Tubingen, Alemania.

11.          “Effect of reducing agents on the immunochemical quantification of gliadins”. Margheritis A, Doña V, Fossati CA, Chirdo FG. Proceedings of the 17th Meeting Working Group on Prolamin Analysis and Toxicity. Pag. 65-70.Octubre 3-6, 2002. London, UK.. Ed. Stern M Verlag Wissenchaftliche Scripten  2003

12.          “Interference of denaturing and reducing agents on gliadin/antibody interaction.”.Doña V., Fossati C.A. and Chirdo F.G. Proceeding of the 18th Meeting of the European Working Group on Prolamin Analysis and Toxicity. 2 al 5 de Octubre, 2003. Estocolmo. Suecia. Ed. M. Stern.Verlag Wissenchaftliche Scripten 2004. pag 51-58

13.         Development of immunochemical and molecular biology tools for the study of TG2 function and mapping function of the antibody reactivity in serum samples”. Bayardo M., Allegretti Y, Ferrara F., Di Niro R , Sblattero D and Chirdo F. Meeting of the European Working Group on Prolamin Analysis and Toxicity. 30/9 – 3/10 200419. Praga, Rep. Checa. Ed. by M Stern, Verlag Wissenchaftliche Scripten, 2005. pg. 117-122.

Trabajos Científicos publicados en Textos

1.    "Hibridomas y Anticuerpos Monoclonales". Inmunología e Inmunoquímica: Fundamentos. Cuarta Edición. Capítulo 30, Pág 559-570. Editor: R.A.Margni. Editorial Médica Panamericana. Buenos Aires, 1989. ISBN 950-06-1459-6

2.     “Brucelosis”. Jorge Carlos Wallach y Carlos Alberto Fossati. Temas de Patología Infecciosa. Capítulo 33, Pág. 266-273. Editor: Olindo A. Martino. Colección.: Fundación A. J. Roemmers. Libreros López Editores, 1995.

3.     “Hibridomas y Anticuerpos Monoclonales”. F.A. Goldbaum y C.A. Fossati. Inmunología e Inmunoquímica, Fundamentos. Quinta Edición. Capítulo 37, Pág. 781-797. Editor: R.A.Margni. Editorial Médica Panamericana. Buenos Aires, 1996. ISBN 950-06-1495-2

4.    "Diez Preguntas sobre Brucelosis Humana”. J.C. Wallach, C.A. Fossati, P.C. Baldi. "Infectología para la práctica diaria III". Ed. Daniel Stanboulian. Ediciones FUNCEI. Buenos Aires, 1998. ISBN 950-9848-10-7

5.    “Introducción a la Inmunología: parte I” C.A. Fossati, F.G. Chirdo, G.H. Docena, M. Rumbo. En: Separata 2004. “Fisiopatología Endocrina: Bioquímica y Métodos Diagnósticos”. Pág. 6-20. Dir. M.A. Pisarev y R.S. Calandra. Coord. M.O. Suescun y G.J Juvenal. Montpellier División Delta. Buenos Aires, Argentina. 2004. ISSN 1515-3878

6.    “Caracterización molecular de una proteína citosólica de Brucella y evaluación de su utilidad en el diagnóstico e inmunoprofilaxis de la brucelosis.” Goldbaum FA, Baldi PC, Velikovsky CA, Giambartolomei GH, Wallach JC, Cassataro J, Spitz M, Fossati CA. En: “Inmunología Molecular: Nuevas Fronteras de la Medicina”. Capítulo 22, Pág 239-245. Editor G.A. Rabinovich. Editorial Médica Panamericana , Buenos Aires, Argentina, 2004. ISBN 950-06-1868-0

7.    ”Inmunoglobulinas” F.A. Goldbaum, F. G. Chirdo y C.A. Fossati. “Introducción a la Inmunobiología” Capítulo 12. Pág 303-342. Editores Penimpede E, Stanchi O, Gómez C. .Editorial de la Universidad Nacional de La Plata, La Plata, Argentina, 2004. ISBN 950-34-0259-x

8.     “Immunochemical Methods for Detection of Probiotics”. Analía G. Abraham, María Serradell, Graciela L. Garrote, Alberto C. Fossati, and Graciela L. De Anton. in  “Probiotics in Food Safety an Human Health”. Eds. Prof. Ipek Goktepe and Dr. Vijay Juneja. Taylor Francis Group. Book Division. Boca Raton, Fl. USA. 2005 ISBN 1-57444-514-6

9.     “Brucella”. R.A. Bowden, P.C. Baldi, J. Cassataro, D.J. Comerci, S. Estein, C.A. Fossati, G.H. Giambartolomei, F.A. Goldbaum, J.C. Wallach. Brucella, en: “Microbiología Veterinaria”. N.O. Stanchi y col. (Editores). Editorial Inter Médica.Buenos Aires  Capítulo 39, pp. 281-293. 2007. ISBN 978-950-555-321-1

10.          “Respuesta inmune: Anticuerpos, alergias, vacunas y reproducción humana”. A. Cauerhff, G. Docena, C. Fossati, F. Goldbaum. Catálogo: Ciencias Naturales y Exactas. Colección: Colección Ciencia Joven.  Editorial:  EUDEBA (2006), Buenos Aires,  ISBN : 950-23-1482-4

 

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